10x Genomics, Inc. operates as a life sciences technology company.
The company focuses on building innovative products and solutions to interrogate, understand, and master biology. The company's integrated solutions include instruments, consumables, and software for analyzing biological systems at a resolution and scale that matches the complexity of biology. The company has built deep expertise across diverse disciplines, including chemistry, biology, hardware, and software. Innovations in all...
10x Genomics, Inc. operates as a life sciences technology company.
The company focuses on building innovative products and solutions to interrogate, understand, and master biology. The company's integrated solutions include instruments, consumables, and software for analyzing biological systems at a resolution and scale that matches the complexity of biology. The company has built deep expertise across diverse disciplines, including chemistry, biology, hardware, and software. Innovations in all of these areas have enabled the deployment of the company's rapidly expanding suite of products, which allow its customers to interrogate biological systems at previously inaccessible resolution and scale. The company's products has enabled researchers to make fundamental discoveries across multiple areas of biology, including oncology, immunology, and neuroscience.
Since launching its first product in mid-2015 through December 31, 2024, the company has sold 7,039 instruments to researchers around the world, including academic and translational researchers, and biopharmaceutical companies.
Portfolios
Resolution and scale are the imperatives that underlie the company's products and technology. The company's solutions are designed to enable understanding biology at the right level of biological resolution, such as at the level of the single cell or at high spatial resolution of tissues and organs. The company's products enable measuring up to millions of single cells or tissue sample positions. Each of the company's platforms is designed to interrogate a major class of biological information, enabling researchers to understand the complexities of biology at a spatial and cellular level. Collectively, the company's platforms enable researchers to interrogate, understand, and master biology at the appropriate resolution and scale.
Single Cell Portfolio
The company's single cell portfolio, powered by its Chromium platform, includes microfluidic chips and related consumables, and its Chromium X Series and legacy Chromium instruments. Chromium enables high-throughput analysis of individual biological components. The company's Chromium instruments serve as precisely engineered reagent delivery systems, partitioning samples into individual components, which can exceed one million. Each partition is paired with proprietary gel beads bearing unique barcodes that allow researchers to identify the contents of each partition and distinguish them from the contents of other partitions. Once biological material in each partition is barcoded, it can then be pooled and sequenced together. Partitioning and barcoding give researchers the ability to measure many discrete biological materials and/or perform many different experiments in parallel, providing tremendous resolution and scale. Chromium enables multiomic readouts, including gene expression, protein (cell surface and intracellular), chromatin, V(D)J, CRISPR/guide RNAs (gRNAs), and antigens, has broad sample compatibility (formalin-fixed paraffin-embedded (FFPE), fresh, fresh frozen, paraformaldehyde (PFA) fixed tissue, DSP/methanol fixed peripheral blood mononuclear cells (PBMCs), and whole blood), and delivers high performance, including high cell recovery rates (CRE), high sensitivity, robustness, and reproducibility.
Spatial Portfolio
The company's spatial portfolio is powered by its Visium and Xenium platforms and aims to bring together the worlds of histology and genomics.
The Visium platform: The company's Visium platform empowers researchers to identify where biological components are located and how they are arranged with respect to each other, otherwise referred to as ‘spatial analysis.’ The Visium platform uses high-density DNA arrays, which have DNA barcode sequences that encode the physical location of biological analytes within a sample, such as a tissue section, allowing the spatial location of the analytes to be ‘read out’ using sequencing to create a visual map of the analytes across the sample. Similar to partitioning, spatial barcoding with large numbers of oligos on an array can unlock tremendous insights, providing high-resolution molecular information to visualize the whole transcriptome and protein expression, paired with same section hematoxylin and eosin (H&E) or infrared (IR) imaging data, across biological tissues.
Xenium platform: The company's Xenium platform for in situ analysis is designed to give scientists the ability not only to locate and type cells in their tissue context, but also to address a variety of specific questions based on previous knowledge of their sample potentially discovered using its Chromium and Visium platforms. The Xenium Analyzer instrument enables researchers to detect and preserve the cellular location of hundreds of RNA targets directly in a fresh frozen or FFPE tissue section without the need for conventional sequencing, providing researchers with a detailed map of gene expression patterns without sacrificing resolution or target number.
Software
The company's software is essential to accelerating the mastery of biology. As the company's portfolios unlock new levels of resolution and scale, they generate entirely new types of data at greater volumes and complexity than ever before. Cell Ranger, introduced alongside the company's Chromium platform, has become a trusted scRNA-seq processing pipeline in scientific literature. The company has extended the same principles of accessibility, scalability, and reliability across all its platforms, ensuring that researchers can move from raw data to discovery with ease. Today, the company provides a comprehensive and scalable software ecosystem that supports every stage of the research workflow, from experiment planning to data processing to visualization and exploration. By removing barriers to adoption, the company's tools help researchers generate high-quality data, achieve repeatable success, and seamlessly scale their experiments. Loupe Browser (Chromium and Visium) enables intuitive single-cell, spatial, and multiomic data visualization, helping researchers explore gene expression, cellular interactions, and more—turning complex datasets into interactive insights that accelerate discovery. Xenium Explorer enables intuitive in situ data visualization, allowing researchers to explore subcellular gene expression, spatial organization, and tissue-scale patterns with ease. It transforms complex imaging and transcriptomic data into interactive insights, accelerating discovery in spatial biology.
Commercial Organization and Strategy
Since launching its first product in mid-2015, the company has expanded its commercial operations and now sells its products in over 50 countries. The company's customers primarily include academic, government, biopharmaceutical, biotechnology, and other institutions focused on life sciences research. The company sells its products primarily through its own direct sales force in North America and certain regions of Europe. The company sells its products through third-party distributors in certain regions of Asia, Europe, Oceania, Central America, South America, the Middle East, and Africa.
For the year ended December 31, 2024, no single customer, including distributors, represented greater than 10% of the company's business. For the year ended December 31, 2024, sales to academic institutions represented approximately 67% of the company's direct sales revenue.
The company's sales and marketing efforts are targeted at the principal investigators, research scientists, department heads, research laboratory directors, and core facility directors at leading academic institutions, biopharmaceutical companies, and publicly and privately funded research institutions who control buying decisions. The company increases awareness of its products among its target customers through direct sales calls, trade shows, seminars, academic conferences, web presence, social media, and other forms of marketing. The company supplements these traditional marketing efforts by fostering an active online community of users of its products consisting of communities, forums, and blogs with internally generated and user-generated content. The company also provides education and training resources, both online and in person.
Suppliers and Manufacturing
The company's Pleasanton, California, Singapore, and Taiwan manufacturing operations are ISO 9001:2015 certified, which covers design, development, manufacturing, distribution, service, and sales.
Consumables
The majority of the company's consumable products are manufactured at its facilities. These manufacturing operations include, among other operations, gel bead generation, surfactant synthesis, and emulsion oil formulation, reagent formulation and tube filling, certain of the company's microfluidic chips, kit assembly and packaging, as well as analytical and functional quality control testing.
Instruments
The company outsources manufacturing for its Chromium, Visium, and Xenium instruments to qualified contract manufacturers who have represented to the company that they maintain ISO 13485 certification. The company performs optical and final assembly, instrument integration, and testing of its Xenium instrument in-house.
Intellectual Property
Worldwide, the company owned or exclusively in-licensed over 1,290 issued or allowed patents and 1,300 pending patent applications as of December 31, 2024. The company also licenses additional patents on a non-exclusive and/or territory-restricted basis.
The company seeks trademark registration to protect key trademarks, such as its 10X, 10X GENOMICS, CHROMIUM, VISIUM, and XENIUM marks; however, it has not yet registered all of its trademarks in all of its current and potential markets. The company owns registered trademarks on 10X GENOMICS and product-related brand names in the United States and worldwide.
The patents the company owns expire beginning in 2030, and the patents it exclusively in-licenses expire beginning in 2028.
History
The company was founded in 2012. It was incorporated in 2012. The company was formerly known as 10X Technologies, Inc. and changed its name to 10x Genomics, Inc. in November 2014.